I've been slapping pages on the web for a decade now. A long time ago, after a great deal of experimentation, I concluded that Verdana was your best bet when designing a commercial site, particularly if that site was for a software vendor.
Before we all had to have blogs, we had personal sites. When this site was younger, I was always changing the font family. I remember when I first switched the markup over to an external CSS file and feeling the power you get when a single edit in a single file changed the font on every page. I abused that power by trying Arial, Courier, Times New Roman, Georgia, and yes, Verdana.
A few years ago I decided I'd stick with Verdana. It always seemed the safest. Most people had it installed on their computer, for starters, and it was highly legible. Verdana was my default font and I was done messing with it. Until today, that is.
The vast majority of you are reading this in Georgia. I'm going to ride Georgia through the long weekend. Let me know what you think in the comments.